Highest contrast colour for annotation of greyscale image

When making figures for research papers I often have to do line annotations on greyscale images, such as the example below:

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The problem, as can be seen in the image, is that a colour that has high contrast in the light areas of the image is often hardly visible in the dark parts.

What colour, or set of colours, have the highest contrast in this situation?


Having tried a stroke I think it offers the easiest approach to make any colour stand out regardless of the background tone:

enter image description here

Source : Link , Question Author : geometrikal , Answer Author : mayersdesign

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